Description
DAPT is an inhibitor of gamma-secretase (IC50 in human primary neurons = 115 nM for total Abeta or 200 nM for Abeta42 specifically) (1). Oral consumption of DAPT in mice and rats has reduced the amount of Abeta in brain extract, cerebrospinal fluid and plasma (2,3). DAPT also blocks Notch signaling, promoting neuronal differentiation (4). DAPT has also been shown to enhance iPS cells without the KLF4 and CMYC oncogenes (5)