Description
Alpha-Cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. Alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced expression of inducible COX-2 at both the mRNA and the protein levels, downregulated the production and mRNA expression of the inflammatory cytokine IL-6. Alpha-Cyperone inhibited actin cytoskeleton polymerization induced by APEC-O78 through down regulating the expression of Nck-2, Cdc42 and Rac1