Description
MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2uM, Ki of 2.1uM, and also is an inducer of the NRF2 pathway; upregulates the acetylation of nuclear H3 histone substrates lysine-56 and -27 in wild-type primary cortical neurons (DIV11) without effect on lysine-14 of H3 histone, induces transcriptional activation of the NRF2 pathway in HD and wild-type neuronal cells; significantly protects against mHTTex1-induced neurodegeneration in HD models