Description
A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26uM for recombinant HIV-1 RT; exhibits IC50>440uM for DNA polymerases alpha and delta; blocks the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates and has low cellular cytotoxicity; retains significant activity against mutant RTs (K103N, Y181C). HIV Infection Approved