Description
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14alpha-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22uM, respectively; shows MIC values 0.032 to >8ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2ug/ml, and exhibits activity in vivo.Fungal Infection Phase 1 Clinical