Description
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96nM) and C1s (IC50=1.6nM); displays 3.4-fold and 200-fold bette than that of trypsin, respectively; inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46nM and 330nM, respectively); blocks the reverse passive Arthus (RPA) reaction in rats.Thrombosis Phase 1 Discontinued