Description
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46nM in biochemical assays; strongly suppresses the SYK and JAK family kinase signaling pathways measured as pLAT and pSTAT levels, respectively; showed anti-proliferative activity in a broad panel of human cancer cell lines; exhibits significant efficacy in inhibiting tumor growth in a multiple myeloma (H929) xenograft model. Blood Cancer Phase 2 Clinical