Description
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15nM; essentially inactive (IC50s>50uM) against HCV Pol, HIV RT, HIV RNase-H, and human alpha/beta/gamma Pol; shows inhibitory activity against the wild type virus and a selection of mutants; the first HIV-integrase inhibitor for the treatment of HIV-1 infection. HIV Infection Approved