Description
A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2uM); displays >10-fold selectivity over other histone acetyltransferases; inhibits Wnt3a-inducible TOPFLASH-luciferase activity with IC50 of 1.5uM, exhibits remarkable specificity toward beta-catenin-1 function and selectively blocks the Wnt signal required for ventral development; robustly and selectively kills cancer cells that harbor Wnt-activating mutations