Description
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75nM, showed 73-fold and 45-fold selectivity relative to PKCalpha and PKCepsilon for in vitro binding activity resepctively; induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCdelta S299 phosphorylation in intact cells