Description
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24nM) and reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14nM), shows efficacy against ADV-resistant HBV mutations; strongly inhibits core gene expression (at 100 to 200nM), suppresses virus accumulation in the supernantant of HepAD38 cells; inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice. HBV Infection Phase 3 Clinical