Description
Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E; inhibits ZIKV PF13-251013-18 with IC90 of 4.0uM, interacts with recombinant, soluble ZIKV E (ZIKV sE) in biolayer interferometry experiments with a KD of 2.1uM; inhibits other flavivirus pathogens, inhibits DENV fusion by targeting E; also inhibits West Nile reporter virus with IC50 of 2.9uM