Description
A potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110alpha/gamma/delta/beta and mTOR (p70S6K) with IC50 of 4nM /5nM /7nM /75nM /6nM, respectively; effectively and specifically blocks the dysfunctional activation of the PI3K pathway, inducing G (1) arrest; demonstrates antitumor activity in in vivo models of human cancer.Kidney Cancer Phase 2 Discontinued