Description
A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-gamma and IL-17 production in human CD4+ T cells with IC50 of 1792nM and 57nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases