Description
A cyclic peptide ligand of αVβ3 integrin (IC50 = 37.5 nM); has been conjugated to various radiolabels or fluorescent probes for the visualization of αVβ3-mediated neoangiogenesis or optical imaging of αVβ3-expressing tumors in live mice; has also been conjugated to SN38 to form a prodrug that targets αVβ3-overexpressing cells and induces cytotoxicity in KB cells