dBET6 from Cayman Chemical

A PROTAC that drives BRD4 degradation; binds to BRD4 (IC50 = 14 nM) and induces its degradation at 100 nM, leading to a global inhibition of transcription in MOLT-4 cells; reduces leukemic burden in a MOLT-4 T-ALL mouse xenograft model when administered at a dose of 7.5 mg/kg twice per day