Description
A dual inhibitor of sEH and COX-2 (IC50s = 0.009 and 1.26 µM, respectively); selective for sEH and COX-2 over COX-1 (IC50 = >100 µM); increases latency to paw withdrawal in the von Frey mechanical assay in a rat model of LPS-induced inflammatory pain at 10 mg/kg; inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice, as well as reduces the number of metastases in a murine Lewis lung carcinoma model, at 30 mg/kg per day; reduces body and hepatic weights, as well as hepatic triglyceride and cholesterol levels and collagen deposition in a mouse model of high-fat diet-induced NAFLD