Description
A soluble epoxide hydrolase inhibitor (IC50s = 0.155, 0.041, and 0.044 µM for the human, rat, and mouse enzymes, respectively); selective for sEH over FAAH (IC50 = 10.8 µM for the human enzyme); inhibits production of NF-κB (IC50 = 8.80 µM) and activates Nrf2 (EC50 = 35.24 µM) in Neuro2a cells; increases the paw withdrawal threshold in a mouse model of LPS-induced inflammatory pain at 100 mg/kg