Description
A positive allosteric modulator of mGluR5; potentiates glutamate-, quisqualate-, or 3,5-dihydroxyphenylglycine-induced calcium transients in CHO cells expressing human mGluR5 (EC50s = 0.021, 0.642, and 2.4 µM, respectively); enhances quisqualate-induced phosphatidylinositol hydrolysis in rat hippocampal slices (EC50 = 0.42 µM); improves spatial alternation retention in the Y-maze special alternation task in rats