Description
A BMI1 inhibitor; inhibits proliferation of OVCAR-4 and OV-90 cells (IC50s = ~0.1 µM for both); induces BMI1 degradation in, and apoptosis of, the same cells; reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MDS-L cells at 3 and 0.03 µM, respectively; reduces tumor growth in a OV-90 orthotopic mouse model of ovarian cancer at 15 mg/kg, biweekly