Description
An SHP-1 activator; activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 cells at 10 µM; inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 µM); decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis at 10 and 20 mg/kg