Description
KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 nM for the adenosine A1 receptors. KF21213 showed a slightly higher affinity for the A2A receptors and a much lower affinity for the A1 receptors than KF18446 (Ki= 5.9 nM for A2A receptors and Ki= 1600 nM for the A1 receptors)