Description
Ensemble Compound 159 is a peptide inhibitor of IL-17A that binds to IL-17A and/or inhibits formation of the IL-17A-IL-17RA complex via an ELISA assay, an HT29-GROα cell based functional assay, a rheumatoid arthritis synovial fibroblast (RASF) assay, and surface plasmon resonance (SPR, Kd < 100 nM) based biophysical binding assessment