Description
Kanglemycin A (KglA) is related to rifampicin, an antibiotic that functions by binding to bacterial RNA polymerase. KglA binds bacterial RNA polymerase at the rifampicin-binding pocket but maintains potency against RNA polymerases containing rifampicin-resistant mutations. KglA has antibiotic activity against rifampicin-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis