Description
It is produced by the strain of Nannizzia gypsea var. incurvata IFO 9228. It can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with IC50 of 18 µmol/L, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 µmol/L. It also inhibits [14C] oleic acid from forming cholesterol esters with IC50 of 0.65 µmol/L