Description
D-NMAPPD is an inhibitor of ceramidase. It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but doesn't have effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. It also increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells