Description
RJR 2429, a heterocyclic substituted pyridine compound, is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 ± 17 nM;Emax = 110 ± 09% vs.nicotine). It induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM)