Description
Salermide is a SIRT1 and SIRT2 inhibitor displaying a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases. Salermide induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours