SLV 320 from BOC Sciences

SLV 320 is a potent and selective adenosine A1 receptor antagonist (Ki = 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors, respectively). SLV320 prevents nephrectomy-dependent rise in plasma levels of creatinine kinase (CK), ALT and AST. SLV 320 inhibits cardiac fibrosis and attenuates albuminuria, without affecting blood pressure in animal models of chronic renal failure