Description
PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki= 0.096, 0.125, 0.31 and 0.55 µM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively). PPDA with its high affinity and distinct subunit selectivity may represent an important lead compound for the development of NMDA receptor antagonists of yet greater selectivity