Description
O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also an inhibitor of GPR18. It does not bind to CB1 or CB2 receptors at concentrations up to 30 µM. It inhibits endothelium-dependent vasodilation and cell migration induced by abnormal-cannabidiol in vitro and in whole animals. It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells