Description
CyPPA is a positive modulator of the small conductance calcium-activated potassium channels. It is selective for KCa2.2 (SK2) and KCa2.3 (SK3) channels with EC50 values of 14 and 5.6 µM for KCa2.2 and KCa2.3 respectively, but it shows no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels. So it can be used for distinguishing SK2 and SK3 from SK1 and IK. It is also used to evaluate the roles of SK2 and SK3 in such diverse processes as uterine muscle contraction, dopamine signaling and memory encoding. It reduces the activity of dopaminergic neurons, counteracts hyperdopaminergic behaviors induced by methyl phenidate and inhibits dopamine release