Description
An ACE2 inhibitor (IC50 = 0.44 nM); selective for ACE2 over ACE and CPDA (IC50s = >100 and 27 µM, respectively); inhibits ACE2 hydrolysis of angiotensin I in vitro at 1 µM; inhibits the protein-protein interaction between ACE2 and the SARS-CoV-2 spike glycoprotein; inhibits exogenous recombinant ACE2-induced prevention of angiotensin II-induced hypertension in mice