Description
An inhibitor of Aurora A kinase activity (IC50 = 48 nM) and the Aurora A-N-Myc protein-protein interaction; inhibits several CDKs, FGFRs, MEKs, and PDGFRs, as well as FLT3, KIT, and RET at 10 µM; induces degradation of N-Myc in SK-N-BE(2) neuroblastoma cells (EC50 = 223 nM); prevents S-phase entry in SK-N-BE(2) cells at 1 µM; reduces tumor growth and increases survival in a MYCN-amplified SMS-KCN neuroblastoma mouse xenograft model 25 mg/kg