Description
A flavonoid glycoside and phytoestrogen with diverse biological activities; scavenges hydroxyl radicals in a cell-free assay (IC50 = 178 µg/ml); inhibits the formation of TBARS in egg yolk (IC50 = 86 µg/ml); activates thyroid hormone receptor- or estrogen receptor-mediated transcription in GH3 and MCF-7 cells, respectively, in reporter assays at 200 µM; inhibits thapsigargin-induced production of PGE2 in isolated rat peritoneal macrophages at 10 and 30 µM; inhibits trabecular bone loss in a mouse model of ovariectomy-induced osteoporosis at 60 mg/kg