Description
A derivative of maytansine; cytotoxic to SK-BR-3 cells (IC50 = 3.3 nM); selectivity cytotoxic to a variety of CD205-expressing human cancer cells (EC50s = 0.1-1.32 nM) over non-CD205-expressing cells (EC50s = 14.2-22.66 nM) and reduces tumor growth in various mouse xenograft and PDX cancer models when conjugated to a humanized CD205-targeting monoclonal antibody