Description
A 5-HT1A and 5-HT1B receptor agonist; binds to 5-HT1A and 5-HT1B receptors (IC50s = 9.5 and 6.6 nM, respectively); selective for these receptors over 5-HT2 receptors in cell-free assays (IC50 = 5,120 nM); inhibits methiothepin-induced tritium efflux in tritium preloaded rat frontal cortical slices (pA2 = 6.27); potentiates cocaine-induced increases in nucleus accumbens dopamine levels, as well as the reinforcing effects of cocaine self-administration, in rats at 3 mg/kg