Description
A CSF1R inhibitor (IC50 = 3.2 nM); selective for CSF1R over KIT and FLT3 (IC50s = 20 and 190 nM, respectively); reduces CSF1-induced phosphorylation of CSF1R and ERK1/2 in N13 microglia at 0.1-1,000 nM; reduces spinal motor neuron degeneration and increases the latency to fall in the rotarod test in the P301S mouse model of tauopathy; reduces increases in the colonic weight to length ratio, as well as decreases colonic infiltration of macrophages, neutrophils, and CD3+ T cells, in an adoptive T cell transfer-induced mouse model of colitis at 15 mg/kg