Description
An activator of microtubule polymerization; induces aggregation of isolated bovine brain tubulin; inhibits binding of vinblastine to tubulin in cell-free assays at 100 µM; induces mitotic block in HeLa cells when used at a concentration of 68 nM; cytotoxic to various cancer cell lines (IC50s = 18-40 nM); reduces tumor growth in a LoVo colon adenocarcinoma mouse xenograft model at 20 mg/kg, i.v