Description
A DNA topoisomerase I inhibitor; inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay; inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively); inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively); reduces tumor growth in a U937 leukemia mouse xenograft model at 4 mg/kg twice per week