Description
An adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor); inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 µM); reverses NECA-induced suppression of IFN-γ secretion in CD8+ T cells; reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models