Description
A COX-inactive enantiomer of flurbiprofen; inhibits γ-secretase activity in vitro; reduces formation of Aβ42 and improves axonal transport in young Aβ-plaque free mice in the Tg2576 transgenic model of Alzheimer's disease; inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages; reduces paw edema in a rat model of zymosan-induced inflammation at 1, 3, and 9 mg/kg; suppresses prostate tumor cell growth in vitro and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia