Description
An inhibitor of Atox1 and CCS; binds to purified Atox1 and CCS (Kds = 6.8 and 8.2 µM, respectively); inhibits the interaction between Atox1 and domain 4 of ATP7B in the presence of zinc in a FRET-based assay at 100 µM; increases copper and ROS levels and decreases COX activity and lipid biosynthesis in H1299 cells at 10 µM; inhibits the proliferation of H1299, K562, MDA-MB-231, and 212LN cancer cells, but not PIG1, HDF, HaCaT, or MCF-10A cells, in a concentration-dependent manner; reduces tumor growth in an H1299 mouse xenograft model at 100 mg/kg per day