Description
A inhibitor of endosomal trafficking; increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells at 20 µM; inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 µM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and Hd-CDT, in various cell types; inhibits infection of Vero and HeLa cells by the low pH-dependent LCMV (Armstrong strain) and influenza A/WSN/33 viruses, respectively