Description
A STING agonist; induces expression of an ISG54 luciferase reporter in HepAD38 cells that constitutively express human cGAS and STING; increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human PBMCs at 50 µM; inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at 50 µM