Description
A histamine H2 receptor antagonist; reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2); inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats from 0.03-3 mg/kg