Description
A VEGFR2 inhibitor (IC50 = 0.16 µM in a cell-free assay); selectively inhibits VEGFR2 over ALK2, ALK5, and AMPK (IC50s = 3.5, >30, and 8 µM, respectively, in a cell-free assay); inhibits growth of H460 and A549 cancer cells (GI50s = 13.3 and 2.8 µM, respectively) and reduces VEGF-induced tubule formation in HUVECs (IC50 = 1 µM)