Description
A diterpene alkaloid with diverse biological activities; blocks IK current in rat hippocampal neurons (IC50 = 146 µM); reduces Aβ40-induced increases in IK current and cytotoxicity in primary rat cortical neurons; inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 µM); exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm)