CB-5083 from Cayman Chemical

Product Specs
ItemCB-5083
CompanyCayman Chemical
Price $267.00Supplier Page View Company Product Page
Catalog Number19311
FormatA crystalline solid
Research AreaApoptosis, Cancer, Cell Biology, Cell Death, Endomembrane System & Vesicular Trafficking, ER Protein Folding, Proteolysis, Ubiquitin/Proteasome System
Molecular Weight413.5
Quantity10 mg
Purity≥95%
TypeInhibitors
OriginUSA
FormulaC24H23N5O2
Storage-20

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Identification of ERAD-dependent degrons for the endoplasmic reticulum lumeneLifeNovember 12, 2024Rachel Sharninghausen, Jiwon Hwang, Devon D Dennison, Ryan D BaldridgeDMSO, treated with 50 nM bortezomib (APExBIO, A2614), or treated with 1 μM CB5083 (Cayman Chemicals, 19311) for the indicated time periods prior to collection. For combination treatments, cells were pretreated

(2) Identification of ERAD-dependent degrons for the endoplasmic reticulum lumenElifeNovember 12, 2024Rachel Sharninghausen, Jiwon Hwang, Devon D Dennison, Ryan D BaldridgeDMSO, treated with 50 nM bortezomib (APExBIO, A2614), or treated with 1 μM CB5083 (Cayman Chemicals, 19311) for the indicated time periods prior to collection. For combination treatments, cells were pretreated

(3) VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy modelsThe Journal of clinical investigationMay 23, 2024Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Mann CN, Lee EB.of MG132 and the addition of 30 μg/μL of CHX (C1988, Sigma-Aldrich) with DMSO or 2.5 μM of CB5083 (19311, Cayman Chemical Company) for 6 hours. To test efficacy of UP109, UP158, UP163, or UP12 activator in

(4) TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2CellsApril 25, 2024Ahmed N, Preisinger C, Wilhelm T, Huber M.μg/mL CHX (Sigma-Aldrich, #01810) for the indicated times. VCP activity was inhibited by CB-5083 (#19311) or NMS-873 (#17674) (1 μM; both from Cayman, Ann Arbor, MI, USA). 2.5. RNA Preparation and Quantitative

(5) Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2ElifeApril 15, 2024Ibtisam Ibtisam, Alexei F KisselevC-3022","Proteasome Inhibitors," "Chemical compound, drug",CB-5083,Cayman Chemicals,"CAS# 1542705-92-9, Cat# 19311","p97 inhibitor," "Chemical compound, drug",CHAPS (3-((3-cholamidopropyl) dimethylammonio)–1-propanesulfonate),Thermo

(6) Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2eLifeApril 15, 2024Ibtisam Ibtisam, Alexei F KisselevC-3022","Proteasome Inhibitors," "Chemical compound, drug",CB-5083,Cayman Chemicals,"CAS# 1542705-92-9, Cat# 19311","p97 inhibitor," "Chemical compound, drug",CHAPS (3-((3-cholamidopropyl) dimethylammonio)–1-propanesulfonate),Thermo

(7) UBXN1 maintains ER proteostasis and represses UPR activation by modulating translationEMBO ReportsJanuary 2, 2024Brittany A Ahlstedt, Rakesh Ganji, Sirisha Mukkavalli, Joao A Paulo, Steve P Gygi, Malavika RamanTriton X-100 (97063-864) was purchased from VWR. CB-5083 were purchased from Cayman Chemical Company (19311). Bortezomib (S1013) was purchased from Selleckchem. EndoH (P0702S) was purchased from New England Biolabs.

(8) Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearancebioRxivOctober 9, 2023Jessica M. Phan, Benjamin C. Creekmore, Aivi T. Nguyen, Darya D. Bershadskaya, Nabil F. Darwich, Edward B. LeeMG132 and the addition of 30μg/μL of cycloheximide, CHX (C1988, Sigma) with DMSO or 2.5μM of CB5083 (19311, Cayman Chemical Company,Ann Arbor, MI, USA) for 6 hours. To test efficacy of UP109 activator, cells

(9) Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequenceCell reportsApril 25, 2023Wang J, Han S, Ye J.,New England Biolabs,P0704 PNGase F,Promega,V4831 Proteinase K,Roche,RPROTK-RO CB-5083,Cayman Chemical,19311 Doxycycline hyclate,Sigma-Aldrich,D9891 ,, Critical commercial assays,Critical commercial assays,Critical

(10) Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancersPLOS ONEDecember 8, 2022Navneet Singh, Lindsey Romick-Rosendale, Miki Watanabe-Chailland, Lisa M. Privette Vinnedge, Kakajan Komurovwere incubated with lapatinib was from (Selleck Chemicals, S1028), 250nM CB-5083 (Cayman Chemicals, 19311), and 15μM guanabenz (Tocris, 0885). Lapatinib drug treatment Lapatinib-resistant cell lines were

(11) Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporterCell chemical biologyMarch 17, 2022Read ML, Brookes K, Thornton CEM, Fletcher A, Nieto HR, Alshahrani M, Khan R, Borges de Souza P, Zha L, Webster JRM, et al.Proteins" ,, Astemizole,Sigma-Aldrich,Cat# 2861 Carebastine,Sigma-Aldrich,Cat# 24186 CB-5083,Cayman Chemical,Cat# 19311 Chloroquine Diphosphate,Sigma-Aldrich,Cat# C6628 Clotrimazole,Sigma-Aldrich,Cat# C6019 DBeQ,Sigma-Aldrich,Cat#

(12) SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transportDevelopmental cellFebruary 28, 2022Yan R, Chen K, Wang B, Xu K.120299 Dithiothreitol (DTT),Thermo Fisher,Cat# R0861 MG132,Tocris,Cat# 1748 CB-5083,Cayman Chemical,Cat# 19311 Thapsigargin,Invitrogen,Cat# T7459 JF635 HaloTag ligand,Lavis Lab,Promega Cat# GA1120 D-biotin,J&K,Cat#

(13) Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargoThe Journal of cell biologyFebruary 7, 2022Devireddy S, Ferguson SM.h after prosaposin siRNA transfection, HeLa cells were treated with either DMSO control or CB-5083 (19311; Cayman Chemical Co.) for 7 h before isolating protein lysates for immunoblot analysis. RUSH live-cell imaging

(14) Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific mannerScience (New York, N.Y.)June 25, 2021Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP.mM, Millipore Sigma 1062771000), TAK-243 (1 μM, ChemieTek CT-M7243), CB-5083 (1 μM, Cayman Chemical 19311), bafilomycin A1 (10 nM, Cayman Chemical 11038), cycloheximide (100 μg/ml, Sigma-Aldrich C7698), and

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CB-5083 from Cayman Chemical

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Cayman Chemical

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CB-5083 from Cayman Chemical

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