Description
A multi-kinase inhibitor (IC50s = 6, 2, 4, 5, and 32 nM for FGFR1, VEGFR2, Tie-2, RSK, and p70S6K, respectively); inhibits growth of OPM2 human multiple myeloma and murine Ba/F3-TEL-FGFR1 leukemia cells in vitro; inhibits tumor angiogenesis in an H460 mouse xenograft model; reduces tumor growth in an HCT116 mouse xenograft model when administered in combination with 5-FU or paclitaxel